THO Complex 2 antibody (AA 101-200) (HRP)

Catalog No. ABIN1413938

Product Details anti-THO Complex 2 Antibody (HRP)

Target: THO Complex 2 (THOC2)

Binding Specificity: AA 101-200

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This THO Complex 2 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human THOC2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for THO Complex 2

Target: THO Complex 2 (THOC2)

Alternative Name: THOC2 (THOC2 Products)

Synonyms: RGD1561623 antibody, THO antibody, Tho2 antibody, fb73e08 antibody, fd21d11 antibody, wu:fb73e08 antibody, wu:fd21d11 antibody, si:bz1o18.2 antibody, CXorf3 antibody, THO2 antibody, dJ506G2.1 antibody, hTREX120 antibody, 6330441O12Rik antibody, D130005M13Rik antibody, Gm1139 antibody, Gm1793 antibody, THO complex 2 antibody, Thoc2 antibody, THOC2 antibody, thoc2 antibody

Background:

Synonyms: THO2, CXorf3, hTREX120, dJ506G2.1, THO complex subunit 2, THOC2

Background: Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim.

Gene ID: 57187

UniProt: Q8NI27