NERP-1 antibody (AA 231-330) (Cy3)

Catalog No. ABIN1411257

Product Details anti-NERP-1 Antibody (Cy3)

Target: NERP-1 (Neuroendocrine Regulatory Peptide 1 (NERP-1))

Binding Specificity: AA 231-330

Reactivity: Mouse, Rat, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NERP-1 antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Mouse, Rat, Zebrafish (Danio rerio)

Predicted Reactivity: Human,Cow,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NERP1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NERP-1

Target: NERP-1 (Neuroendocrine Regulatory Peptide 1 (NERP-1))

Alternative Name: VGF/NERP-1 (NERP-1 Products)

Synonyms: Gm1052 antibody, VGF nerve growth factor inducible antibody, VGF antibody, Vgf antibody

Background:

Synonyms: Nerve growth factor inducible, Neurosecretory protein VGF, VGF, VGF_HUMAN, SCG7, SgVII, Neuroendocrine regulatory peptide-1, NERP-1, NERP1

Background: This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. Nerve growth factor (NGF) is a peptide that plays a key role in the differentiation and survival of neurons in the peripheral nervous system (PNS) and the central nervous system (CNS). VGF is a peptide synthesized and secreted by neurons and is upregulated by NGF in the PC12 cell line. VGF is widely expressed in both the PNS and CNS, but is especially abundant in the adult hypothalamus. VGF plays an essential role in how the brain regulates energy expenditure and body weight. Its expression is rapidly induced by injury, the circadian clock, and neuronal activity.

Gene ID: 7425

UniProt: O15240