Coagulation Factor VIII-Associated 1 (F8A1) (AA 2-80) antibody (Cy3)

Catalog No. ABIN1410687

Product Details

Target: Coagulation Factor VIII-Associated 1 (F8A1)

Binding Specificity: AA 2-80

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Cy3

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Predicted Reactivity: Human,Mouse,Rat,Cow

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HAP40

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Coagulation Factor VIII-Associated 1 (F8A1)

Alternative Name: HAP40/F8a (F8A1 Products)

Synonyms: DXS522E antibody, F8A antibody, HAP40 antibody, F8a antibody, Hap40 antibody, RGD1566014 antibody, f8a antibody, f8a1 antibody, hap40 antibody, dxs522e antibody, MGC147036 antibody, coagulation factor VIII associated 1 antibody, coagulation factor VIII-associated 1 antibody, coagulation factor VIII antibody, F8A1 antibody, F8a1 antibody, f8a1 antibody

Background:

Synonyms: Coagulation factor 8 associated intronic transcript 1, Coagulation factor VIII associated intronic transcript 1, CpG island protein, DXS522E, F8a, F8A1, F8A2, F8A3, Factor 8 associated protein, Factor 8 intron 22 protein, Factor VIII associated protein, Factor VIII intron 22 protein, huntingtin associated protein 40, F8I2_HUMAN.

Background: The Huntingtin protein contains a polyglutamine region, which leads to Huntingtin?s disease (HD) when the number of glutamine repeats exceeds thirty-five. The mutated Huntingtin protein acts within the nucleus to induce neurodegeneration by a cell-specific apoptotic mechanism. The loss of activity of the Huntingtin protein may be contributed to abnormal interactions between the mutant protein and other associated cellular proteins. Huntingtin interacts with a variety of proteins including HAP1, glyceraldehyde phosphate dehydrogenase (GAPDH), HAP40, Rab5 and HIP1. HAP40 mediates the recruitment of Huntingtin by Rab5 onto early endosomes. Specifically, this complex regulates endosome motility, which may be a key event of the pathogenetic process leading to neurodegeneration in HD.