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Humanin antibody (AA 1-24) (Cy3)

MT-RNR2 Reactivity: Human IF (cc), IF (p) Host: Rabbit Polyclonal Cy3
Catalog No. ABIN1410393
  • Target See all Humanin (MT-RNR2) products
    Humanin (MT-RNR2) (Mitochondrially Encoded 16S RNA (MT-RNR2))
    Binding Specificity
    • 15
    • 1
    AA 1-24
    Reactivity
    • 24
    • 3
    • 3
    Human
    Host
    • 27
    Rabbit
    Clonality
    • 27
    Polyclonal
    Conjugate
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Humanin antibody is conjugated to Cy3
    Application
    • 12
    • 12
    • 11
    • 7
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Humanin
    Isotype
    IgG
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C/-80 °C
    Storage Comment
    Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
    Expiry Date
    12 months
  • Target
    Humanin (MT-RNR2) (Mitochondrially Encoded 16S RNA (MT-RNR2))
    Alternative Name
    Humanin (MT-RNR2 Products)
    Synonyms
    MTRNR2 antibody, l-rRNA antibody, RNR2 antibody
    Background

    Humanin, an endogenous anti-apoptotic peptide against Alzheimer disease-related insults, consists of 24 amino acids. The secreted protein is a neuroprotective factor against death induced by several different types of Alzheimer's disease genes. Humanin protects neuronal cells from damage caused by Alzheimer's disease genes, specifically APP (amyloid precursor protein). Humanin acts as a ligand for formyl peptide receptor-like 1 (FPRL1) with APP and utilizes its neuroprotective effects by inhibiting FPRL1 access to APP. The peptide prevents Bax translocation from cytosol to mitochondria. Humanin expression levels may be dependent on defects in energy production in muscles with mitochondrial abnormalities. The peptide has been detected in muscles of patients with the mitochondrial disease chronic progressive external ophthalmoplegia (CPEO). Humanin is mainly expressed in the kidney, heart, liver, testis and skeletal muscles.

    Subcellular location: Secreted

    Synonyms: HN,HUNIN, HUNIN_HUMAN.

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