LRP5L antibody (AA 101-200) (Cy3)

Catalog No. ABIN1410063

Product Details anti-LRP5L Antibody (Cy3)

Target: LRP5L (Low Density Lipoprotein Receptor-Related Protein 5-Like (LRP5L))

Binding Specificity: AA 101-200

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRP5L antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Sheep,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human LRP5L

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for LRP5L

Target: LRP5L (Low Density Lipoprotein Receptor-Related Protein 5-Like (LRP5L))

Alternative Name: LRP5L (LRP5L Products)

Synonyms: LDL receptor related protein 5 like antibody, LRP5L antibody

Background:

Synonyms: Low-density lipoprotein receptor-related protein 5-like protein, LRP-5-like, LRP5L, GP330, LRP5L_HUMAN.

Background: Members of the LDL receptor gene family, including LDLR (low density lipo-protein receptor), LRPs (low density lipoprotein related proteins), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2, are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. Of the known family members, LRP5 is most closely related to LRP1. However, LRP5 has a unique organization of EGF and LDLR repeats compared to other LDLR family members and likely represents a new category in this family. LRP is expressed in rat tibia, specifically in areas of the bone that are involved in remodeling. LRP5 is a Wnt coreceptor that binds to Axin and regulates the canonical Wnt signaling pathway. LRP5 affects bone mass accrual during growth. Mutations in LRP5 cause the autosomal recessive disorder osteoporosis-pseudoglioma syndrome (OPPG). LRP5L is a related protein that exists as two isoforms produced by alternative splicing.