RGMB antibody (AA 58-160) (Cy3)
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- Target See all RGMB Antibodies
- RGMB (RGM Domain Family, Member B (RGMB))
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Binding Specificity
- AA 58-160
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This RGMB antibody is conjugated to Cy3
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Predicted Reactivity
- Human,Mouse,Rat,Dog,Cow,Pig,Horse
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Repulsive Guidance Molecule B
- Isotype
- IgG
- Top Product
- Discover our top product RGMB Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- RGMB (RGM Domain Family, Member B (RGMB))
- Alternative Name
- RGMB/Repulsive Guidance Molecule B (RGMB Products)
- Synonyms
- dragon antibody, DRAGON antibody, 1110059F19Rik antibody, repulsive guidance molecule family member b antibody, repulsive guidance molecule family member B antibody, rgmb antibody, RGMB antibody, Rgmb antibody
- Background
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Synonyms: Dragon, DRG11-responsive axonal guidance and outgrowth of neurite, Repulsive Guidance Molecule B, RGM b, RGM domain family member B, Rgmb, RGMB_HUMAN.
Background: The repulsive guidance molecule (RGM) family of proteins are important in the guidance of growth cones of developing neurons. They are repulsive for a group of axons, those from the temporal half of the retina. RGM have been implicated in both axonal guidance and neural tube closure but as opposed to for ephrins, semaphorins, netrins and slits, no receptor mechanism for RGM activation has been defined. Dorsal root ganglion axons do not respond to RGM but neogenin (a netrin-binding protein which can function as an RGM receptor) expression can spur RGM responsiveness. The RGM proteins are attached to the membrane by a GPI-anchor. Two members of this family, RGMa and RGMb, are expressed in the nervous system. RGMc, also known as Hemojuvelin, is a part of the signaling pathway activating hepcidin and works together with hepcidin to restrict iron absorption in the gut. Defects in the gene encoding for RGMc causes the autosomal recessive disorder juvenile hemochromatosis (JH).
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