HOXA6 antibody (AA 171-233) (HRP)

Catalog No. ABIN1408310

Product Details anti-HOXA6 Antibody (HRP)

Target: HOXA6 (Homeobox A6 (HOXA6))

Binding Specificity: AA 171-233

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HOXA6 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HOXA6/HOX1B

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for HOXA6

Target: HOXA6 (Homeobox A6 (HOXA6))

Alternative Name: HOXA6/HOX1B (HOXA6 Products)

Synonyms: HOX1 antibody, HOX1.2 antibody, HOX1B antibody, Hox-1.2 antibody, homeobox A6 antibody, HOXA6 antibody, hoxa6 antibody, Hoxa6 antibody

Background:

Synonyms: Homeo box 1B, Homeo box A6, Homeobox 1B, Homeobox A6, Homeobox protein Hox A6, Homeobox protein Hox-1B, Homeobox protein Hox-A6 antibody Homeobox protein HoxA6, HOX 1, Hox 1B, HOX1, HOX1.2, Hox1B, HOXA6, HX A6, HXA6, HXA6_HUMAN.

Background: The Hox homeobox genes encode proteins that are transcriptional regulators with an established role in embryonic development. HoxA6 (homeobox A6), also known as HOX1B, is a 233 amino acid protein that localizes to the nucleus. Expressed during embryonic development, HoxA6 functions as a sequence-specific DNA-binding transcription factor that is part of a regulatory mechanism that provides cells with positional identities during development. Via its ability to bind DNA, HoxA6 plays an important role in the regulation of gene expression, as well as morphogenesis and differentiation. The gene encoding HoxA6 maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5 % of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.