BFSP2 antibody (AA 181-280) (Cy3)

Catalog No. ABIN1406667

Product Details anti-BFSP2 Antibody (Cy3)

Target: BFSP2 (Beaded Filament Structural Protein 2, Phakinin (BFSP2))

Binding Specificity: AA 181-280

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BFSP2 antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human BFSP2/Phakinin

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for BFSP2

Target: BFSP2 (Beaded Filament Structural Protein 2, Phakinin (BFSP2))

Alternative Name: Bfsp2/Phakinin (BFSP2 Products)

Synonyms: CP47 antibody, CP49 antibody, CTRCT12 antibody, LIFL-L antibody, PHAKOSIN antibody, AI448593 antibody, CP49INS antibody, BFSP2 antibody, LOC100222605 antibody, Bfsp2 antibody, zgc:103750 antibody, beaded filament structural protein 2 antibody, beaded filament structural protein 2, phakinin antibody, BFSP2 antibody, Bfsp2 antibody, bfsp2 antibody

Background:

Synonyms: 49 kDa cytoskeletal protein, Beaded filament protein CP49, Beaded filament structural protein 2, Beaded filament structural protein 2, phakinin, Bfps2, Cytoskeletal protein, 49 kD, BFSP2, BFSP2_HUMAN, CP47, CP49, Lens fiber cell beaded filament protein CP 47, Lens fiber cell beaded filament protein CP 49,Lens intermediate filament-like light, LL-L, Phakinin, PHAKOSIN.

Background: Phakinin is a membrane-associated and cytoskeletal intermediate filament (IF) protein specific to the eye lens. IFs are cytoskeletal structures that typically contain a head, rod and tail domain. Unlike most IFs, Phakinin completely lacks the C-terminal tail domain thus contributing to the unique structure of the beaded filament that is specific to the lens. Phakinin is required for the assembly of beaded filaments and cytoskeletal networks that are important for the long-term maintenance of optical properties and transparency of the lens. Phakinin copolymerizes with Filensin, another IF protein, to form the 10-nm filamentous structures of the beaded filaments. Phakinin is also capable of self-assembling into filament-like structures that form thicker bundles. Mutations in the gene encoding Phakinin can result in lens cataract.

Gene ID: 3921