ZWILCH antibody (AbBy Fluor® 350)
-
- Target See all ZWILCH Antibodies
- ZWILCH (Zwilch, Kinetochore Associated, Homolog (ZWILCH))
- Reactivity
- Human, Mouse, Rat
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This ZWILCH antibody is conjugated to AbBy Fluor® 350
-
Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human ZWILCH
- Isotype
- IgG
- Top Product
- Discover our top product ZWILCH Primary Antibody
-
-
- Application Notes
- IF(IHC-P) 1:50-200
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
-
- Target
- ZWILCH (Zwilch, Kinetochore Associated, Homolog (ZWILCH))
- Alternative Name
- ZWILCH (ZWILCH Products)
- Synonyms
- CG18639 antibody, CG18729 antibody, Dmel\\CG18729 antibody, Zwilch antibody, hzwilch antibody, kntc1ap antibody, KNTC1AP antibody, hZwilch antibody, 2310031L18Rik antibody, si:ch211-242m18.4 antibody, wu:fb10f09 antibody, zwilch kinetochore protein antibody, CG18729 gene product from transcript CG18729-RA antibody, protein zwilch homolog antibody, Zwilch antibody, zwilch antibody, LOC100374963 antibody, ZWILCH antibody
- Background
-
Synonyms: hZwilch, KNTC1AP, MGC111034, Protein zwilch homolog, ZWILC_HUMAN, zwilch,y ZWILCH protein, Zwilch, kinetochore associated, homolog.
Background: Zwilch is the human homolog of the Drosophila Zwilch protein. The Drosophila Zwilch forms a complex with both ROD Rough Deal) and ZWINT (Zeste-White 10, also designated ZW10) proteins. This complex is important for chromosome segregation because it recruits cytoplasmic Dynein to the kinetochore and plays a crucial role in the spindle checkpoint. The role of Zwilch in complex is thought to be evolutionarily conserved because the human homologs of Zwilch, ZWINT and ROD coimmunoprecipitate in a human cell line called HeLa. The human Zwilch, ZWINT and ROD complex localizes to the kinetochores at prometaphase. Mutations were discovered in Zwilch, ZWINT and ROD during a screen for mutations in alleles encoding putative chromosome instability genes in cases of human colorectal cancer. These mutations may contribute in part to the chromosomal instability phenotype of colorectal tumor cells.
- Gene ID
- 55055
- UniProt
- Q9H900
-