BIN2 antibody (AbBy Fluor® 350)

Catalog No. ABIN1404309

Product Details anti-BIN2 Antibody (AbBy Fluor® 350)

Target: BIN2 (Bridging Integrator 2 (BIN2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BIN2 antibody is conjugated to AbBy Fluor® 350

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human BIN2/BRAP1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for BIN2

Target: BIN2 (Bridging Integrator 2 (BIN2))

Alternative Name: BIN2 (BIN2 Products)

Synonyms: BRAP-1 antibody, BIN2 antibody, bin2l antibody, wu:fi05e01 antibody, zgc:55758 antibody, bridging integrator 2 antibody, bridging integrator 2b antibody, BIN2 antibody, Bin2 antibody, bin2b antibody

Background:

Synonyms: BIN2, BIN2_HUMAN, BRAP 1, Breast cancer associated protein BRAP1, Breast cancer-associated protein 1, Bridging integrator 2.

Background: BAR proteins are characterized by a common N-terminal BAR (bin, amphiphysin and Rvs161/167) domain and are recognized as adaptor proteins that are involved in many cellular processes. BIN1 and BIN2 are BAR proteins that share 61 % sequence similarity. BIN1 (Bridging integrator 1) is a ubiquitously expressed regulatory protein for synaptic vesicle endocytosis. BIN1 also interacts with the transcription factors c-Myc and MyoD, potentially functioning as a tumor suppressor. BIN2, also known as Breast cancer-associated protein 1, is a 565 amino acid protein that interacts with BIN1. In contrast to BIN1, BIN2 lacks tumor suppressor features as well as a c-Myc interacting region. BIN2 shows preferred expression in tissues of hematopoietic origin, with high levels found in spleen, thymus, colon, placenta, lymphoid and granulocytic cells. There are two isoforms of BIN2 that are produced as a result of alternative splicing events.

Gene ID: 51411