C17orf75 antibody (AA 210-260) (Biotin)
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- Target See all C17orf75 Antibodies
- C17orf75 (Chromosome 17 Open Reading Frame 75 (C17orf75))
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Binding Specificity
- AA 210-260
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This C17orf75 antibody is conjugated to Biotin
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human C17orf75
- Isotype
- IgG
- Top Product
- Discover our top product C17orf75 Primary Antibody
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- Application Notes
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WB 1:300-5000
IHC-P 1:200-400 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C for 12 months.
- Expiry Date
- 12 months
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- Target
- C17orf75 (Chromosome 17 Open Reading Frame 75 (C17orf75))
- Alternative Name
- C17orf75 (C17orf75 Products)
- Synonyms
- NJMU-R1 antibody, C17orf75 antibody, DKFZp469B234 antibody, chromosome 18 C17orf75 homolog antibody, chromosome 17 open reading frame 75 L homeolog antibody, chromosome 17 open reading frame, human C17orf75 antibody, chromosome 17 open reading frame 75 antibody, RIKEN cDNA 5730455P16 gene antibody, C18H17orf75 antibody, c17orf75.L antibody, C17H17orf75 antibody, C17orf75 antibody, 5730455P16Rik antibody
- Background
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Synonyms: Njmu R1, Protein kinase Njmu R1, Protein Njmu R1, NJMU_HUMAN.
Background: C17orf75 is a 396 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5 % of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.
- Gene ID
- 64149
- UniProt
- Q9HAS0
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