BRMS1 antibody (AA 151-246) (AbBy Fluor® 350)
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- Target See all BRMS1 Antibodies
- BRMS1 (Breast Cancer Metastasis Suppressor 1 (BRMS1))
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Binding Specificity
- AA 151-246
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This BRMS1 antibody is conjugated to AbBy Fluor® 350
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Cross-Reactivity
- Human, Mouse, Rat
- Predicted Reactivity
- Dog,Pig,Horse
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human BRMS1
- Isotype
- IgG
- Top Product
- Discover our top product BRMS1 Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- BRMS1 (Breast Cancer Metastasis Suppressor 1 (BRMS1))
- Alternative Name
- BRMS1 (BRMS1 Products)
- Synonyms
- MGC98869 antibody, BRMS1 antibody, BRMS1L antibody, AV003220 antibody, AW554636 antibody, si:zc188c22.3 antibody, si:zc194c5.2 antibody, wu:fb57b08 antibody, zgc:56414 antibody, breast cancer metastasis suppressor 1 antibody, breast cancer metastasis-suppressor 1 antibody, breast cancer metastasis suppressor 1 L homeolog antibody, BRMS1 antibody, Brms1 antibody, brms1.L antibody, brms1 antibody
- Background
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Synonyms: Breast cancer metastasis suppressor 1, Breast cancer metastasis-suppressor 1, BRMS-1, BRMS1_HUMAN, DKFZp564A063, MGC95128, AV003220, AW554636.
Background: Breast cancer metastasis-suppressor 1 (BRMS1) is 246 amino acid protein that acts as a mediator of metastasis suppression in several types of cancer including ovarian, lung, bladder, and murine mammary. BRMS1 mRNA is expressed in various tissues, including ovary, prostate, testis, and colon, but the protein is primarily detected in term placenta. BRMS1 suppresses metastasis without inhibiting tumorigenicity by modifying several metastasis-associated phenotypes. BRMS1 may participate in transcriptional regulation by binding to the mSin3/histone deacetylase complex. The expression of BRMS1 in certain cells increases connexin Cx43 expression and reduces connexin Cx32 expression. This produces a gap junction that increases intercellular communication, similar to those found in normal breast tissue. BRMS1 is stabilized by Hsp90 and may inhibit NF-_B activity.
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