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HOXD9 antibody (AA 251-352) (Biotin)

HOXD9 Reactivity: Human WB, ELISA, IHC (fro), IHC (p) Host: Rabbit Polyclonal Biotin
Catalog No. ABIN1399975
  • Target See all HOXD9 Antibodies
    HOXD9 (Homeobox D9 (HOXD9))
    Binding Specificity
    • 14
    • 12
    • 12
    • 7
    • 7
    • 6
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 251-352
    Reactivity
    • 49
    • 26
    • 21
    • 9
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 61
    • 2
    Rabbit
    Clonality
    • 61
    • 2
    Polyclonal
    Conjugate
    • 19
    • 7
    • 6
    • 6
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HOXD9 antibody is conjugated to Biotin
    Application
    • 51
    • 35
    • 13
    • 13
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Pig,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human HOXD9
    Isotype
    IgG
    Top Product
    Discover our top product HOXD9 Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    HOXD9 (Homeobox D9 (HOXD9))
    Alternative Name
    HOXD9 (HOXD9 Products)
    Synonyms
    Hox-4.4 antibody, Hox-5.2 antibody, Xhoxd9 antibody, HOX4 antibody, HOX4C antibody, Hox-4.3 antibody, hoxd9 antibody, z-28 antibody, hoxd9a antibody, homeobox D9 antibody, homeobox D9 S homeolog antibody, homeo box D9 antibody, homeobox D9a antibody, Hoxd9 antibody, HOXD9 antibody, hoxd9.S antibody, hoxd9a antibody, hoxd9 antibody
    Background

    Synonyms: homeobox D9, Homeobox protein Hox D9, Hox 4.3, Hox 5.2, HOX4, HOX4C, RP23 313J15.10, HXD9_HUMAN.

    Background: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. In vivo, the HoxD9 protein interacts with the autoregulatory and cross-regulatory enhancers of the murine HoxB1 and human HoxD9 genes. Specifically, the HoxD9 protein interacts with the human control region (HCR) of the HoxD9 gene, thus inducing transcription of the HoxD9 promoter. HoxD9 may be a multifunctional transcriptional regulator, as it contains different activation domains. Activation of HoxD9 depends on the structure of the target regulatory element, and results in differential cofactor interaction. The HoxD9 protein is expressed in the early stages of mouse joint development, primarily in the articular cartilage. HoxD9 transcripts are also detected in the synovial tissue of arthritic mice, but not in that of normal mice, suggesting that HoxD9 may have a role in the pathology of arthritis. Furthermore, the HoxD9 protein is highly expressed in the synoviocytes of patients with rheumatoid arthritis (RA), but not in osteoarthritis patients. The human HoxD9 protein is also differentially expressed in the human cervical cancer cell line HeLa, but is not expressed in the normal cervix and may thus play a role in tumorigenesis.

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