PMS1 antibody (AA 245-350) (Biotin)

Catalog No. ABIN1399843

Product Details anti-PMS1 Antibody (Biotin)

Target: PMS1 (PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae) (PMS1))

Binding Specificity: AA 245-350

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PMS1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PMS1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for PMS1

Target: PMS1 (PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae) (PMS1))

Alternative Name: PMS1 (PMS1 Products)

Synonyms: PMSL1 antibody, si:dz72b14.2 antibody, si:dz164h20.2 antibody, PMS1 antibody, DKFZp468M105 antibody, pms1 antibody, HNPCC3 antibody, hPMS1 antibody, PMS1 homolog 1, mismatch repair system component antibody, PMS1 homolog 1, mismatch repair system component S homeolog antibody, PMS1 antibody, Pms1 antibody, pms1 antibody, pms1.S antibody

Background:

Synonyms: DNA mismatch repair protein PMS1, HNPCC3, hPMS1, Human homolog of yeast mutL, Mismatch repair gene PMSL1, pms1, PMS1 postmeiotic segregation increased 1 S. cerevisiae, PMS1 postmeiotic segregation increased 1, PMS1 protein homolog 1, PMS1_HUMAN, PMSL1, Rhabdomyosarcoma antigen MU RMS 40.10B, Rhabdomyosarcoma antigen MU RMS 40.10E.

Background: The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45 % of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.

Gene ID: 5378