SPP2 antibody (AA 55-160) (AbBy Fluor® 555)

Catalog No. ABIN1399511

Product Details anti-SPP2 Antibody (AbBy Fluor® 555)

Target: SPP2 (Secreted Phosphoprotein 2 (SPP2))

Binding Specificity: AA 55-160

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPP2 antibody is conjugated to AbBy Fluor® 555

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Rat

Predicted Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SPP24/SPP2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SPP2

Target: SPP2 (Secreted Phosphoprotein 2 (SPP2))

Alternative Name: SPP24 (SPP2 Products)

Synonyms: spp24 antibody, 0610038O04Rik antibody, pp-24 antibody, SPP-24 antibody, SPP24 antibody, GHRG-1 antibody, secreted phosphoprotein 2 antibody, spp2 antibody, Spp2 antibody, SPP2 antibody

Background:

Synonyms: SPP24, SPP-24, Secreted phosphoprotein 24, Secreted phosphoprotein 2, SPP2

Background: SPP24, also known as secreted phosphoprotein 2, is a 211 amino acid secreted protein that belongs to the cystatin superfamily. Expressed in liver and plasma, SPP24 may play a role in coordinating an aspect of bone turnover. The gene that encodes SPP24 maps to human chromosome 2, which consists of 237 million bases encoding over 1,400 genes, making up approximately 8 % of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr syndrome is due to mutations in the ALMS1 gene. Interestingly, chromosome 2 contains what appears to be a vestigial second centromere and vestigial telomeres which gives credence to the hypothesis that human chromosome 2 is the result of an ancient fusion of two ancestral chromosomes seen in modern form today in apes.

Gene ID: 6694

UniProt: Q13103