UBE2J2 antibody (AA 1-100) (Biotin)

Catalog No. ABIN1398757

Product Details anti-UBE2J2 Antibody (Biotin)

Target: UBE2J2 (Ubiquitin-Conjugating Enzyme E2, J2 (UBE2J2))

Binding Specificity: AA 1-100

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBE2J2 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human UBE2J2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for UBE2J2

Target: UBE2J2 (Ubiquitin-Conjugating Enzyme E2, J2 (UBE2J2))

Alternative Name: UBE2J2 (UBE2J2 Products)

Synonyms: NCUBE-2 antibody, NCUBE2 antibody, PRO2121 antibody, 1200007B18Rik antibody, 2400008G19Rik antibody, 5730472G04Rik antibody, AL022923 antibody, Ubc6 antibody, Ubc6p antibody, zgc:162164 antibody, ubiquitin conjugating enzyme E2 J2 antibody, ubiquitin-conjugating enzyme E2J 2 antibody, ubiquitin-conjugating enzyme E2, J2 antibody, ubiquitin-conjugating enzyme E2 J2 antibody, ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast) antibody, ubiquitin conjugating enzyme E2 J2 L homeolog antibody, UBE2J2 antibody, Ube2j2 antibody, LOC5574000 antibody, CpipJ_CPIJ008956 antibody, ube2j2 antibody, uce2 antibody, ube2j2.L antibody, LOC100067387 antibody

Background:

Synonyms: NCUBE-2, NCUBE2, Non-canonical ubiquitin-conjugating enzyme 2, UB2J2_HUMAN, UBC6, UBC6 homolog, ube2j2, Ubiquitin-conjugating enzyme E2 J2.

Background: Ubiquitination is an important molecular mechanism by which abnormal or short-lived proteins are targeted for degradation by the concerted efforts of at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). UBE2J2 (Ubiquitin-conjugating enzyme E2 J2), also known as NCUBE2 (Non-canonical ubiquitin-conjugating enzyme 2), is a 259 amino acid single pass type IV membrane protein that that belongs to the E2 ubiquitin-conjugating enzyme family and is involved in protein degradation. Localized to the membrane of the endoplasmic reticulum (ER), UBE2J2 catalyzes the attachment of ubiquitin to misfolded membrane proteins, thereby targeting them for proteasomal destruction. This ATP-dependent reaction yields AMP, a diphosphate and a ubiquitin-tagged protein and may be a method of quality control within the ER. Two isoforms of UBE2J2 exist due to alternative splicing events.

Gene ID: 118424