PANK1 antibody (AbBy Fluor® 350)

Catalog No. ABIN1398495

Product Details anti-PANK1 Antibody (AbBy Fluor® 350)

Target: PANK1 (Pantothenate Kinase 1 (PANK1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PANK1 antibody is conjugated to AbBy Fluor® 350

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PANK1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PANK1

Target: PANK1 (Pantothenate Kinase 1 (PANK1))

Alternative Name: PANK1 (PANK1 Products)

Synonyms: PANK antibody, 4632412I06Rik antibody, 5430426F23Rik antibody, Pank antibody, Pank1a antibody, Pank1b antibody, panK1beta antibody, PANK1 antibody, im:7149302 antibody, wu:fb51a11 antibody, zgc:158746 antibody, ATCOAA antibody, ATPANK1 antibody, T13D8.31 antibody, T13D8_31 antibody, pantothenate kinase 1 antibody, DKFZp469J1021 antibody, fb79e08 antibody, zgc:63556 antibody, wu:fb79e08 antibody, pantothenate kinase 1 antibody, pantothenate kinase 1b antibody, pantothenate kinase 1a antibody, PANK1 antibody, Pank1 antibody, pank1b antibody, EHI_183060 antibody, pank1a antibody

Background:

Synonyms: coaA, hPanK, hPanK1, PANK, PANK1, PANK1_HUMAN, PANK1a, PANK1b, PanK1beta, Pantothenate kinase 1, Pantothenate kinase, Pantothenic acid kinase 1.

Background: The pantothenate kinase (PANK) family of proteins catalyzes the first step in coenzyme A (CoA). Pantothenate kinase 1 (PANK1) is a 598 amino acid member of the pantothenate kinase family that plays a role in the physiological regulation of the intracellular CoA concentration. Localized to the cytoplasm, PANK1 is strongly inhibited by acetyl-CoA and manyl-CoA, as well as by high concentration of non-esterified CoA (CoASH). Four known isoforms of PANK1 exist as a result of alternative splicing events. Of these isoforms, PANK1a and PANK1b have been identified as the catalytically active isoforms. Isoform PANK1a is most highly expressed in brain, heart, kidney, liver, skeletal muscle and kidney. Isoform PANK1b is detected at much lower levels in kidney, liver, brain and testis and is not detected in heart or skeletal muscle.

Gene ID: 53354

UniProt: Q8TE04

Pathways: Ribonucleoside Biosynthetic Process