T-Box 1 antibody (AA 165-270) (Biotin)

Catalog No. ABIN1398109

Product Details anti-T-Box 1 Antibody (Biotin)

Target: T-Box 1 (TBX1)

Binding Specificity: AA 165-270

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This T-Box 1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TBX1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for T-Box 1

Target: T-Box 1 (TBX1)

Alternative Name: TBX1 (TBX1 Products)

Synonyms: CAFS antibody, CTHM antibody, DGCR antibody, DGS antibody, DORV antibody, TBX1C antibody, TGA antibody, VCFS antibody, mp:zf637-3-000616 antibody, zgc:136724 antibody, TBX1 antibody, dgs antibody, tga antibody, cafs antibody, cthm antibody, dgcr antibody, dorv antibody, vcfs antibody, tbx1c antibody, xtbx1 antibody, tbx1 antibody, T-box 1 antibody, T-box 1 S homeolog antibody, T-box 1 L homeolog antibody, TBX1 antibody, Tbx1 antibody, tbx1 antibody, tbx1.S antibody, tbx1.L antibody

Background:

Synonyms: Brachyury, CAFS, CTHM, DGCR, DGS, DORV, T box 1, T box 1 transcription factor, T box 1 transcription factor C, T box, T box protein 1, T box transcription factor TBX 1, T box transcription factor TBX1, T-box 1, T-box protein 1, T-box transcription factor TBX1, TBX 1, TBX 1C, tbx1, TBX1_HUMAN, TBX1C, Testis specic T box protein, Testis-specic T-box protein, TGA, VCFS.

Background: Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries.Involvement in disease:Haploinsufficiency of the TBX1 gene is responsible for most of the physical malformations present in DiGeorge syndrome (DGS) and velocardiofacial syndrome (VCFS) . DGS is characterized by the association of several malformations: hypoplastic thymus and parathyroid glands, congenital conotruncal cardiopathy, and a subtle but characteristic facial dysmorphology. VCFS is marked by the association of congenital conotruncal heart defects, cleft palate or velar insufficiency, facial dysmorpholgy and learning difficulties. It is now accepted that these two syndromes represent two forms of clinical expression of the same entity manifesting at different stages of life.Defects in TBX1 are a cause of DiGeorge syndrome (DGS) .Defects in TBX1 are a cause of velocardiofacial syndrome (VCFS) .Defects in TBX1 are a cause of conotruncal heart malformations (CTHM). CTHM consist of cardiac outflow tract defects, such as tetralogy of Fallot, pulmonary atresia, double-outlet right ventricle, truncus arteriosus communis, and aortic arch anomalies.

Gene ID: 6899

Pathways: Retinoic Acid Receptor Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation