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MLC1 antibody (AA 321-377) (AbBy Fluor® 350)

Reactivity: Mouse, Rat WB, IF (cc), IF (p) Host: Rabbit Polyclonal AbBy Fluor® 350
Catalog No. ABIN1397898
  • Target See all MLC1 products
    MLC1
    Binding Specificity
    • 14
    • 14
    • 8
    • 5
    • 1
    • 1
    • 1
    • 1
    AA 321-377
    Reactivity
    • 23
    • 15
    • 15
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Mouse, Rat
    Host
    • 37
    • 1
    Rabbit
    Clonality
    • 38
    Polyclonal
    Conjugate
    • 11
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MLC1 antibody is conjugated to AbBy Fluor® 350
    Application
    • 32
    • 20
    • 12
    • 12
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Mouse, Rat
    Predicted Reactivity
    Human,Dog,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human MLC1
    Isotype
    IgG
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    MLC1
    Abstract
    MLC1 Products
    Synonyms
    LVM antibody, MLC antibody, VL antibody, AW048630 antibody, BB074274 antibody, Kiaa0027-hp antibody, WKL1 antibody, mKIAA0027 antibody, si:ch211-192n14.1 antibody, megalencephalic leukoencephalopathy with subcortical cysts 1 antibody, megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human) antibody, MLC1 antibody, Mlc1 antibody, mlc1 antibody
    Background

    Synonyms: KIAA0027, LVM, Megalencephalic leukoencephalopathy with subcortical cysts 1, Membrane protein MLC1, MLC, MLC-1, MLC1_HUMAN, VL, WKL1.

    Background: MLC1 is a 377 amino acid multi-pass membrane protein that may serve as a non-selective neuronal cation channel in brain. Mutant MLC1 proteins that show impaired folding have been corrected in vitro with the addition of a Ca(2+)-ATPase inhibitor, curcumin. Mutations in the gene encoding MLC1 is the cause of megalencephalic leukoencephalopathy with subcortical cysts, also known as van der Knaap disease, a rare syndrome characterized early in life by progressive brain destruction causing mental retardation and incoordination. Single nucleotide polymorphisms within the MLC1 gene may be associated with periodic catatonia, but there seems to be conflicting evidence on whether or not the gene is implicated in general schizophrenia.

    Gene ID
    23209
    UniProt
    Q15049
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