PCGF1 antibody (AA 51-150) (Biotin)

Catalog No. ABIN1397136

Product Details anti-PCGF1 Antibody (Biotin)

Target: PCGF1 (Polycomb Group Ring Finger 1 (PCGF1))

Binding Specificity: AA 51-150

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCGF1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PCGF1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for PCGF1

Target: PCGF1 (Polycomb Group Ring Finger 1 (PCGF1))

Alternative Name: PCGF1 (PCGF1 Products)

Synonyms: PCGF1 antibody, 2010002K04Rik antibody, NSPC1 antibody, RNF3A-2 antibody, RNF68 antibody, AU024121 antibody, Nspc1 antibody, nspc1 antibody, si:zc207o21.2 antibody, polycomb group ring finger 1 antibody, polycomb group ring finger 1 L homeolog antibody, PCGF1 antibody, pcgf1 antibody, Pcgf1 antibody, pcgf1.L antibody

Background:

Synonyms: PCGF1_HUMAN, PCGF1, Nervous system Polycomb-1, NSPc1, Polycomb group RING finger protein 1, RING finger protein 68, RNF68.

Background: PCGF1 is a component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. It represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). PCGF1 als promotes cell cycle progression and also enhances cell proliferation, thus it may have a positive role in tumor cell growth.