Fibrillin 2 antibody (AA 1001-1200) (Biotin)

Catalog No. ABIN1395541

Product Details anti-Fibrillin 2 Antibody (Biotin)

Target: Fibrillin 2 (FBN2)

Binding Specificity: AA 1001-1200

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Fibrillin 2 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Fibrillin 2

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for Fibrillin 2

Target: Fibrillin 2 (FBN2)

Alternative Name: Fibrillin 2 (FBN2 Products)

Synonyms: CCA antibody, DA9 antibody, BC063774 antibody, Fib-2 antibody, mKIAA4226 antibody, sne antibody, sy antibody, FBN2 antibody, fibrillin 2 antibody, fibrillin 3 antibody, FBN2 antibody, Fbn2 antibody, FBN3 antibody

Background:

Synonyms: CCA, congenital contractural arachnodactyly Marfanoid-like, DA9, FBN2, FBN2_HUMAN, fibrillin 2 congenital contractural arachnodactyly, Fibrillin-2.

Background: Extracellular glycoproteins fibrillin-1 and -2 are major components of connective tissue microfibrils. Fibrillin-2 containing microfibrils regulate the early process of elastic fiber assembly in tissue. Mutations in the fibrillin-2 gene resulting in impaired assembly of fibrillin-2 may lead to molecular congenital contractural arachnodactyly. Fibrillin-2 constitutes the backbone of microfibrils which insert directly into the lamina densa of basement membranes. Epithelial cells primarily deposit fibrillin into the extracellular matrix in a nonfibrillar form. Mutations in the 8-cysteine motif of Fibrillin-2 alters its binding to microfibril-associated glycoprotein-1 (MAGP-1), which may increase the severity of congenital contractural arachnodactyly.

Pathways: Maintenance of Protein Location, SARS-CoV-2 Protein Interactome