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SHROOM2 antibody (AA 701-850) (AbBy Fluor® 555)

SHROOM2 Reactivity: Human IF (cc), IF (p) Host: Rabbit Polyclonal AbBy Fluor® 555
Catalog No. ABIN1395341
  • Target See all SHROOM2 Antibodies
    SHROOM2 (Shroom Family Member 2 (SHROOM2))
    Binding Specificity
    • 14
    • 7
    • 6
    • 6
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    AA 701-850
    Reactivity
    • 45
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 44
    • 1
    Rabbit
    Clonality
    • 45
    Polyclonal
    Conjugate
    • 12
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SHROOM2 antibody is conjugated to AbBy Fluor® 555
    Application
    • 21
    • 19
    • 12
    • 12
    • 5
    • 4
    • 3
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human APXL
    Isotype
    IgG
    Top Product
    Discover our top product SHROOM2 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    SHROOM2 (Shroom Family Member 2 (SHROOM2))
    Alternative Name
    APXL (SHROOM2 Products)
    Synonyms
    SHROOM2 antibody, APXL antibody, apxl antibody, shrm2 antibody, HSAPXL antibody, 4832440C16 antibody, Apxl antibody, C630003H05Rik antibody, Shrm2 antibody, shroom family member 2 antibody, SHROOM2 antibody, shroom2 antibody, Shroom2 antibody
    Background

    Synonyms: Apical like protein, Apical like protein APXL protein, apical protein of Xenopus-like, Apical protein Xenopus laevis like, apical protein, Xenopus laevis-like, apical protein-like, apical protein-like Xenopus laevis, Apical-like protein, APX homolog of Xenopus, C630003H05Rik, DKFZp781J074, FLJ39277, HSAPXL, Liver regeneration-related protein LRRG167, Protein Apxl, Protein Shroom2, Shrm2, SHRM2_HUMAN, SHROOM 2, Shroom family member 2, shroom2.

    Background: APXL is a 1,616 amino acid protein that localizes to a variety of locations within the cell, including the cytoplasm, the cytoskeleton, the cell junction and the apical cell membrane. Containing one ASD1 domain, one ASD2 domain and one PDZ domain, APXL interacts with F-Actin and is thought to mediate endothelial cell morphology during cell spreading, possibly regulating melanosome biogenesis and inducing _ Tubulin redistribution. APXL is expressed in kidney, brain, lung, pancreas and placenta and is overexpressed in melanomas, suggesting a role in tumor transformation and metastasis. The gene encoding APXL maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes. In conjunction with chromosome Y, chromosome X is responsible for sex determination. There are a number of conditions related to an abnormal number and combination of sex chromosomes, some of which include Turner's syndrome, color blindness, hemophilia and Duchenne muscular dystrophy.

    Pathways
    Cell-Cell Junction Organization, Asymmetric Protein Localization
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