MPDZ antibody (AA 388-480) (Biotin)

Catalog No. ABIN1395157

Product Details anti-MPDZ Antibody (Biotin)

Target: MPDZ (Multiple PDZ Domain Protein (MPDZ))

Binding Specificity: AA 388-480

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MPDZ antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MUPP1/MPDZ

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for MPDZ

Target: MPDZ (Multiple PDZ Domain Protein (MPDZ))

Alternative Name: MUPP1/MPDZ (MPDZ Products)

Synonyms: HYC2 antibody, MUPP1 antibody, AI225843 antibody, B930003D11Rik antibody, multiple PDZ domain crumbs cell polarity complex component antibody, multiple PDZ domain protein antibody, Multiple PDZ domain protein antibody, inactivation-no-after-potential D protein antibody, multiple pdz domain protein, putative antibody, MPDZ antibody, Mpdz antibody, mpz-1 antibody, LOC5569990 antibody, Smp_168960 antibody

Background:

Synonyms: MPDZ, Multi PDZ domain protein 1, Multi-PDZ domain protein 1, multiple PDZ domain protein, MPDZ_HUMAN.

Background: MPDZ is a 2,042 amino acid peripheral membrane protein that colocalizes with SR-2C on the apical membrane of epithelial choroid plexus cells. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas, MPDZ causes clustering of SR-2C, a serotonin receptor, at the cell surface. MPDZ is member of the NMDAR signaling complex that is involved in regulating AMPAR potentiation and synaptic plasticity in excitatory synapses. As a tight junction protein in epithelial cells, MPDZ interacts with SSTR3, a G-protein-coupled receptor, to regulate transepithelial permeability in a pertussis toxin sensitive manner. MPDZ, along with Kir4.2, may form a complex with other proteins in the nephron and regulate ion transport. MPDZ contains one L27 domain and thirteen PDZ domains.

Pathways: Synaptic Membrane, Phototransduction