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MPDZ antibody (AA 388-480) (AbBy Fluor® 488)

MPDZ Reactivity: Human FACS, IF (cc), IF (p) Host: Rabbit Polyclonal AbBy Fluor® 488
Catalog No. ABIN1395154
  • Target See all MPDZ Antibodies
    MPDZ (Multiple PDZ Domain Protein (MPDZ))
    Binding Specificity
    • 15
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 388-480
    Reactivity
    • 23
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 23
    Rabbit
    Clonality
    • 23
    Polyclonal
    Conjugate
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MPDZ antibody is conjugated to AbBy Fluor® 488
    Application
    • 13
    • 12
    • 12
    • 8
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human
    Predicted Reactivity
    Mouse,Rat,Dog,Cow,Sheep,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human MUPP1/MPDZ
    Isotype
    IgG
    Top Product
    Discover our top product MPDZ Primary Antibody
  • Application Notes
    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    MPDZ (Multiple PDZ Domain Protein (MPDZ))
    Alternative Name
    MUPP1/MPDZ (MPDZ Products)
    Synonyms
    HYC2 antibody, MUPP1 antibody, AI225843 antibody, B930003D11Rik antibody, multiple PDZ domain crumbs cell polarity complex component antibody, multiple PDZ domain protein antibody, Multiple PDZ domain protein antibody, inactivation-no-after-potential D protein antibody, multiple pdz domain protein, putative antibody, MPDZ antibody, Mpdz antibody, mpz-1 antibody, LOC5569990 antibody, Smp_168960 antibody
    Background

    Synonyms: MPDZ, Multi PDZ domain protein 1, Multi-PDZ domain protein 1, multiple PDZ domain protein, MPDZ_HUMAN.

    Background: MPDZ is a 2,042 amino acid peripheral membrane protein that colocalizes with SR-2C on the apical membrane of epithelial choroid plexus cells. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas, MPDZ causes clustering of SR-2C, a serotonin receptor, at the cell surface. MPDZ is member of the NMDAR signaling complex that is involved in regulating AMPAR potentiation and synaptic plasticity in excitatory synapses. As a tight junction protein in epithelial cells, MPDZ interacts with SSTR3, a G-protein-coupled receptor, to regulate transepithelial permeability in a pertussis toxin sensitive manner. MPDZ, along with Kir4.2, may form a complex with other proteins in the nephron and regulate ion transport. MPDZ contains one L27 domain and thirteen PDZ domains.

    Pathways
    Synaptic Membrane, Phototransduction
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