GARP antibody (AA 856-960) (Biotin)

Catalog No. ABIN1395121

Product Details anti-GARP Antibody (Biotin)

Target: GARP (CNGB1) (Cyclic Nucleotide Gated Channel beta 1 (CNGB1))

Binding Specificity: AA 856-960

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GARP antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CNGB1

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for GARP

Target: GARP (CNGB1) (Cyclic Nucleotide Gated Channel beta 1 (CNGB1))

Alternative Name: CNG4/GARP (CNGB1 Products)

Synonyms: CNCG2 antibody, CNCG3L antibody, CNCG4 antibody, CNG4 antibody, CNGB1B antibody, GAR1 antibody, GARP antibody, RCNC2 antibody, RCNCb antibody, RCNCbeta antibody, RP45 antibody, Gm1959 antibody, Cngb1b antibody, CNGB1 antibody, si:ch211-160j6.1 antibody, cyclic nucleotide gated channel beta 1 antibody, cyclic nucleotide gated channel beta 1a antibody, CNGB1 antibody, Cngb1 antibody, cngb1a antibody

Background:

Synonyms: CNCG2, CNCG3L, CNCG4, CNG 4, CNG-4, CNG channel 4, CNG channel beta 1, CNG4, CNGB 1, CNGB1, CNGB1B, Cyclic nucleotide gated cation channel 4, Cyclic nucleotide gated cation channel, Cyclic nucleotide gated cation channel beta 1, Cyclic nucleotide gated cation channel gamma, Cyclic nucleotide gated cation channel modulatory subunit, Cyclic nucleotide gated channel photoreceptor cGMP gated 3 gamma like, Cyclic nucleotide gated channel beta 1, GAR1, Glutamic acid rich protein, RCNC2, RCNCb, RCNCbeta, RP45, CNGB1_HUMAN.

Background: Cyclic nucleotide-gated (CNG) cation channels are heteromeric complexes made up of principal alpha and modulatory beta subunits (1,2). The alpha subunits consist of CNG1-3 and form functional cation channels by themselves (1,2). The beta subunits consist of CNG4-6 and, unlike the alpha subunits, do not form functional channels, but rather modify the properties of channels (1,2). CNG channels are essential components of olfactory and visual transduction (1,2). In olfactory neurons, CNG2, CNG4.3 and CNG5 form Ca2+ permeable channels, which open and depolarize the cell in response to cAMP (1-3). In rod photoreceptors, CNG1 and CNG4.1 combine to form Ca ion permeable channels, which give rise to a current in response to cGMP (1-3). CNG3 and CNG6 are expressed in cone receptors and may combine to form a native cGMP-activated channel (2,3). CNG channels have been implicated in other areas (4-6). CNG1 is also expressed in medium-sized and small-sized arteries, suggesting a role for CNG in the regulation of arterial blood pressure and of blood supply to different regions (4). CNG1, CNG4.1 and CNG4.2 have been detected in the rat pineal gland (5). CNG2, CNG4.3 and CNG5 are present in GT1 cell lines and may play a role in the secretion of gonadotropin-releasing hormone (6).

UniProt: Q14028

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction