RPGRIP1L antibody (AA 41-140) (AbBy Fluor® 647)

Catalog No. ABIN1394250

Product Details anti-RPGRIP1L Antibody (AbBy Fluor® 647)

Target: RPGRIP1L (RPGRIP1-Like (RPGRIP1L))

Binding Specificity: AA 41-140

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RPGRIP1L antibody is conjugated to AbBy Fluor® 647

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RPGRIP1L

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for RPGRIP1L

Target: RPGRIP1L (RPGRIP1-Like (RPGRIP1L))

Alternative Name: RPGRIP1L (RPGRIP1L Products)

Synonyms: si:ch1073-301i20.1 antibody, mks5 antibody, cors3 antibody, jbts7 antibody, nphp8 antibody, CORS3 antibody, FTM antibody, JBTS7 antibody, MKS5 antibody, NPHP8 antibody, 1700047E16Rik antibody, 4931437C01 antibody, Ftm antibody, Nphp8 antibody, RGD1311099 antibody, RPGRIP1 like antibody, RPGRIP1-like antibody, Protein fantom antibody, Rpgrip1-like antibody, RPGRIP1L antibody, rpgrip1l antibody, mks-5 antibody, Rpgrip1l antibody

Background:

Synonyms: CORS 3, CORS3, Fantom, FTM, JBTS 1, JBTS 7, JBTS1, JBTS7, Joubert syndrome 1, Joubert syndrome 7, Meckel syndrome, type 1, RPGRIP1-like, Meckel syndrome, type 5, MKS 5, MKS5, NPHP 8, NPHP8, nephrocystin 8, Protein fantom, Retinitis pigmentosa GTPase regulator interacting protein 1 like, RPGR interacting protein 1 like protein, RPGRIP1 like protein, FTM_HUMAN.

Background: RPGRIP1L is a 1,315 amino acid protein that belongs to the RPGRIP1 family and is thought to function in programmed cell death, craniofacial development and formation of the left-right axis. Existing as two alternatively spliced isoforms that localize to the cytoplasm, cytoskeleton, centrosome and cilium basal body, RPGRIP1L interacts with nephrocystin-4 and is moderately expressed in brain, retina and kidney. Containing two C2 domains, RPGRIP1L is encoded by a gene that maps to human chromosome 16q12.2. Defects in the gene encoding RPGRIP1L are the cause of Joubert syndrome type 7 (JBTS7), COACH syndrome (COACHS) and Meckel syndrome type 5 (MKS5).

Pathways: DNA Replication, Regulation of G-Protein Coupled Receptor Protein Signaling, Synthesis of DNA