NEUROD2 antibody (AA 121-250) (Biotin)

Catalog No. ABIN1394095

Product Details anti-NEUROD2 Antibody (Biotin)

Target: NEUROD2 (Neurogenic Differentiation 2 (NEUROD2))

Binding Specificity: AA 121-250

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NEUROD2 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Neuro D2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for NEUROD2

Target: NEUROD2 (Neurogenic Differentiation 2 (NEUROD2))

Alternative Name: Neuro D2 (NEUROD2 Products)

Synonyms: NEUROD2 antibody, ndrf antibody, MGC145932 antibody, Ndrf antibody, bHLHa1 antibody, ndr2 antibody, wu:fj49a11 antibody, zNdr2 antibody, NDRF antibody, neuronal differentiation 2 antibody, neurogenic differentiation 2 antibody, NEUROD2 antibody, neurod2 antibody, Neurod2 antibody

Background:

Synonyms: bHLHa1, Class A basic helix-loop-helix protein 1, class A basic helix loop helix protein 1, NDF2_HUMAN, NDR2, NDRF, Neuro-D2, NeuroD-related factor, NeuroD2, Neurogenic dferentiation factor 2, NDF2_HUMAN, neuroD related factor, NeuroD2, neurogenic basic helix loop helix protein, neurogenic dferentiation 2, Neurogenic dferentiation factor 2, neuronal dferentiation 2.

Background: Members of the myogenic determination family are basic helix-loop-helix (bHLH) proteins that can be separated into two classes, both of which work together to activate DNA transcription. Class A proteins include the ubiquitously expressed E-box binding factors, namely E2A, ITF-2 and HEB, while class B proteins, such as MyoD, myogenin and Neuro D (BETA2), are transiently expressed and exhibit a much more limited tissue distribution. Working in opposition to these positively acting factors are a specialized group of basic helix-loop-helix (bHLH) transcription factors that function as dominant negative regulators and are involved in cell lineage determination and differentiation. Neuro D2 (neurogenic differentiation 2), also known as NDRF, NEUROD2 or bHLHa1, is a 382 amino acid nuclear protein that contains one bHLH domain and functions to induce neurogenic differentiation, playing an important role in the maintenance and determination of cell fate.