NGRN antibody (AA 96-200) (Biotin)

Catalog No. ABIN1394083

Product Details anti-NGRN Antibody (Biotin)

Target: NGRN (Neugrin, Neurite Outgrowth Associated (NGRN))

Binding Specificity: AA 96-200

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NGRN antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Neugrin

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for NGRN

Target: NGRN (Neugrin, Neurite Outgrowth Associated (NGRN))

Alternative Name: Neugrin (NGRN Products)

Synonyms: Ngrn antibody, zgc:136784 antibody, dsc92 antibody, Neugrin antibody, DKFZp469B131 antibody, DSC92 antibody, AW552001 antibody, neugrin, neurite outgrowth associated antibody, ngrn antibody, NGRN antibody, Ngrn antibody

Background:

Synonyms: DSC92, FI58Gm, Mesenchymal stem cell protein DSC92, Neugrin, Neugrin neurite outgrowth associated, Neurite outgrowth associated protein, Neurite outgrowth-associated protein, Ngrn, NGRN_HUMAN, Spinal cord-derived protein FI58G.

Background: Neugrin, also known as NGRN, mesenchymal stem cell protein DSC92, neurite outgrowth-associated protein or spinal cord-derived protein FI58G, is a 291 amino acid protein that plays a role in neuronal differentiation and belongs to the neugrin family. As both a secreted and nuclear protein, neugrin exists as two alternatively spliced isoforms and is highly expressed in skeletal muscle, brain and heart. Neugrin is upregulated in neuroblastostoma cells by retinoic acid treatment and is encoded by a gene that maps to human chromosome 15q26.1. Chromosome 15 houses over 700 genes and comprises nearly 3 % of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.