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Shootin-1 (SHTN1) (AA 21-130) antibody (AbBy Fluor® 350)

SHTN1 Reactivity: Human, Rat WB, IF (cc), IF (p) Host: Rabbit Polyclonal AbBy Fluor® 350
Catalog No. ABIN1393767
  • Target See all Shootin-1 (SHTN1) Antibodies
    Shootin-1 (SHTN1)
    Binding Specificity
    • 14
    • 2
    • 1
    • 1
    AA 21-130
    Reactivity
    • 24
    • 17
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Rat
    Host
    • 24
    Rabbit
    Clonality
    • 24
    Polyclonal
    Conjugate
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AbBy Fluor® 350
    Application
    • 18
    • 12
    • 12
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human, Rat
    Predicted Reactivity
    Mouse,Cow,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Shootin/KIAA1598
    Isotype
    IgG
    Top Product
    Discover our top product SHTN1 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    Shootin-1 (SHTN1)
    Alternative Name
    Shootin/KIAA1598 (SHTN1 Products)
    Synonyms
    Kiaa1598 antibody, Shootin1 antibody, mKIAA1598 antibody, shootin 1 antibody, SHTN1 antibody, Shtn1 antibody
    Background

    Synonyms: DKFZp686A0439, hypothetical protein FLJ11122, Kiaa1598, MGC40476, Putative uncharacterized protein KIAA1598, Shootin 1, Shootin-1, SHOT1_HUMAN.

    Background: Shootin1 is a 631 amino acid protein that belongs to the shootin family. The shootin1 protein contains three coiled-coil domains, a proline-rich region and interacts with RUFY3. Shootin1 is involved in the generation of internal asymmetric signals required for neuronal polarization. The shootin1 protein acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K activity. By accumulating asymmetrically in a single neurite before polarization, shootin1 leads to axon induction for polarization, additionally the absence of shootin1 from the nascent axon's siblings by competition prevents the formation of surplus axons. Existing as seven alternatively spliced isoforms, the shootin1 gene is conserved in chimpanzee, dog, mouse, rat, chicken and zebrafish, and maps to human chromosome 10q25.3.

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