KALRN antibody (AA 1401-1500) (AbBy Fluor® 488)

Catalog No. ABIN1393756

Product Details anti-KALRN Antibody (AbBy Fluor® 488)

Target: KALRN (Kalirin, RhoGEF Kinase (KALRN))

Binding Specificity: AA 1401-1500

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KALRN antibody is conjugated to AbBy Fluor® 488

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KALRN/Duo

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for KALRN

Target: KALRN (Kalirin, RhoGEF Kinase (KALRN))

Alternative Name: KALRN/Duo (KALRN Products)

Synonyms: ARHGEF24 antibody, CHD5 antibody, CHDS5 antibody, DUET antibody, DUO antibody, HAPIP antibody, TRAD antibody, KALRN antibody, 2210407G14Rik antibody, AV235988 antibody, E530005C20Rik antibody, Gm539 antibody, Hapip antibody, Duo antibody, Kalirin antibody, kalirin RhoGEF kinase antibody, kalirin, RhoGEF kinase antibody, kalirin antibody, kalirin RhoGEF kinase L homeolog antibody, putative kalirin antibody, KALRN antibody, LOC460643 antibody, Kalrn antibody, kalrn antibody, kalrn.L antibody, LOC100473997 antibody, Smp_162970 antibody

Background:

Synonyms: Duo, FLJ16443, HAPIP, Huntingtin associated protein interacting protein duo , Huntingtin-associated protein-interacting protein, Kalirin isoform 2, Kalirin, KALRN , KALRN_HUMAN , Protein Duo, RhoGEF kinase, Serine/threonine kinase with Dbl and pleckstrin homology domains , Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain, TRAD.

Background: HAP1 (huntingtin-associated protein 1) binds to huntingtin (1). Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington?s disease (HD) (2,3). The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region (1). HAP1 shows neuronal localization and moves with huntingtin in nerve fibers (4,5). HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem (1). Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons (6). Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function.

Pathways: Neurotrophin Signaling Pathway