GBX2 antibody (AA 251-348) (Biotin)

Catalog No. ABIN1393687

Product Details anti-GBX2 Antibody (Biotin)

Target: GBX2 (Gastrulation Brain Homeo Box 2 (GBX2))

Binding Specificity: AA 251-348

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GBX2 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Gbx2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for GBX2

Target: GBX2 (Gastrulation Brain Homeo Box 2 (GBX2))

Alternative Name: Gbx2 (GBX2 Products)

Synonyms: gbx-2 antibody, fd07f12 antibody, wu:fd07f12 antibody, GBX2 antibody, D130058E05Rik antibody, Gbx-2 antibody, MMoxA antibody, Stra7 antibody, gbx2 antibody, gastrulation brain homeobox 2 antibody, gastrulation brain homeobox 2, gene 2 L homeolog antibody, gbx2 antibody, GBX2 antibody, Gbx2 antibody, gbx2.2.L antibody

Background:

Synonyms: Gastrulation and brain-specic homeobox protein 2, Gastrulation brain homeo box 2 , Gastrulation brain homeo box 2, gbx2, GBX2_HUMAN, Homeobox protein GBX 2 , Homeobox protein GBX 2, Homeobox protein GBX-2, Homeobox protein STRA7, Mmoxa.

Background: The isthmic organizer signals at the mid/hindbrain boundary (MHB) regulate the development and differentiation of the vertebrate caudal midbrain and the anterior hindbrain. The MHB forms at the boundary of expression between homeobox genes Gbx2 and Otx2. Gbx2 and Otx2 play distinct, essential roles in MHB positioning and development. During development, the GBX2 gene is expressed in the anterior hindbrain. Specifically, Gbx2 negatively regulates Otx2 expression along the anterior-posterior axis, Gbx2(-) mutants demonstrate an expanded Otx2 domain. During development, the GBX2 gene is expressed in the anterior hindbrain. Gbx2 is expressed in the adult brain, spleen and female genital tract. The GBX2 gene is over-expressed in human prostate cancer cell lines (TSU-prl, PC3, DU145 and LNCaP). Furthermore, downregulation of Gbx2 expression restricts tumorigenicity in human prostate cancer cell lines, which suggests that Gbx2 expression may be required for growth of malignant prostate cells.

Pathways: Dopaminergic Neurogenesis