CBLN2 antibody (AA 151-224) (Biotin)

Catalog No. ABIN1393489

Product Details anti-CBLN2 Antibody (Biotin)

Target: CBLN2 (Cerebellin 2 Precursor (CBLN2))

Binding Specificity: AA 151-224

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBLN2 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CBLN2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for CBLN2

Target: CBLN2 (Cerebellin 2 Precursor (CBLN2))

Alternative Name: CBLN2 (CBLN2 Products)

Synonyms: MGC64397 antibody, si:dkey-82k12.11 antibody, 6330593N19Rik antibody, A730004O05 antibody, zgc:163051 antibody, cerebellin 2 precursor antibody, cerebellin 2 precursor L homeolog antibody, cerebellin 2a precursor antibody, cerebellin 2 precursor protein antibody, cerebellin 2b precursor antibody, CBLN2 antibody, cbln2.L antibody, cbln2 antibody, cbln2a antibody, Cbln2 antibody, cbln2b antibody

Background:

Synonyms: A730004O05, Cbln2, CBLN2_HUMAN, Cerebellin 2, Cerebellin 2 precursor, Cerebellin-2, OTTHUMP00000163726.

Background: Cerebellin (CER), which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3), and Cerebellin 4 (Cbln4), comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. CER and it metabolite des-Ser1-cerebellin are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 and 3 assemble into homomeric and heteromeric complexes, thereby influencing each other?s degradation and secretion. Cerebellin 3 is not able to form homomeric complexes, and can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of CER has been found in the brain of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role for CER in the pathology of these diseases.