CBLN2 antibody (AA 151-224) (AbBy Fluor® 488)

Catalog No. ABIN1393486

Product Details anti-CBLN2 Antibody (AbBy Fluor® 488)

Target: CBLN2 (Cerebellin 2 Precursor (CBLN2))

Binding Specificity: AA 151-224

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBLN2 antibody is conjugated to AbBy Fluor® 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CBLN2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CBLN2

Target: CBLN2 (Cerebellin 2 Precursor (CBLN2))

Alternative Name: CBLN2 (CBLN2 Products)

Synonyms: MGC64397 antibody, si:dkey-82k12.11 antibody, 6330593N19Rik antibody, A730004O05 antibody, zgc:163051 antibody, cerebellin 2 precursor antibody, cerebellin 2 precursor L homeolog antibody, cerebellin 2a precursor antibody, cerebellin 2 precursor protein antibody, cerebellin 2b precursor antibody, CBLN2 antibody, cbln2.L antibody, cbln2 antibody, cbln2a antibody, Cbln2 antibody, cbln2b antibody

Background:

Synonyms: A730004O05, Cbln2, CBLN2_HUMAN, Cerebellin 2, Cerebellin 2 precursor, Cerebellin-2, OTTHUMP00000163726.

Background: Cerebellin (CER), which was originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor Cerebellin 1, also designated precerebellin 1 or Cbln1. Four propeptides, Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3), and Cerebellin 4 (Cbln4), comprise the precerebellin subfamily within the C1q protein family. Cerebellin family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions. CER and it metabolite des-Ser1-cerebellin are also expressed in several extra-cerebellar tissues, including adrenal gland. Cerebellin 1, 2 and 3 assemble into homomeric and heteromeric complexes, thereby influencing each other?s degradation and secretion. Cerebellin 3 is not able to form homomeric complexes, and can only be secreted upon forming a heteromeric complex with Cerebellin 1. Decreased concentrations of CER has been found in the brain of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting a role for CER in the pathology of these diseases.