RNF19A antibody (AA 621-720) (AbBy Fluor® 647)
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- Target See all RNF19A Antibodies
- RNF19A (Ring Finger Protein 19A (RNF19A))
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Binding Specificity
- AA 621-720
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This RNF19A antibody is conjugated to AbBy Fluor® 647
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Predicted Reactivity
- Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human DORFIN/RNF19
- Isotype
- IgG
- Top Product
- Discover our top product RNF19A Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- RNF19A (Ring Finger Protein 19A (RNF19A))
- Alternative Name
- DORFIN/RNF19 (RNF19A Products)
- Synonyms
- RNF19 antibody, RNF19A antibody, AA032313 antibody, Dorfin antibody, Rnf19 antibody, UIP117 antibody, Ubce7ip2 antibody, XYbp antibody, ring finger protein 19A, RBR E3 ubiquitin protein ligase antibody, ring finger protein 19A antibody, RNF19A antibody, Rnf19a antibody
- Background
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Synonyms: Dorfin, Double ring finger protein, Double ring-finger protein, E3 ubiquitin-protein ligase RNF19A, p38, p38 protein, Ring finger protein 19, RING finger protein 19A, Ring IBR ring domain containing protein Dorfin, RN19A_HUMAN, RNF19, RNF19A, Ubce7ip2, UIP117, XYbp, AA032313, DKFZP566B1346.
Background: Dorfin is a multi-pass membrane, RING-IBR type, E3 ubiquitin-protein ligase. It is widely expressed with highest levels found in heart and ubiquitous expression throughout the central nervous system. Dorfin functions by accepting ubiquitin in the form of a thioester from UBCH7 and UBC8 and then transferring it to the targeted substrates. Dorfin is responsible for ubiquitylating synphilin-1, CaSR and mutant variants of SOD-1, a protein at fault for familial ALS (amyotrophic lateral sclerosis). Dorfin physically interacts with VCP (Valosin-containing protein) via its C-terminus. Together these two proteins are associated with the formation of ubiquitylated inclusions (UBIs) that characterize many neurodegenerative disorders, such as Parkinson?s disease and ALS. This association with UBIs suggests that Dorfin plays an important role in the disease process.
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