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ZFYVE27 antibody (AA 341-411) (Biotin)

ZFYVE27 Reactivity: Human, Rat, Mouse WB, ELISA, IHC (fro), IHC (p) Host: Rabbit Polyclonal Biotin
Catalog No. ABIN1393261
  • Target See all ZFYVE27 Antibodies
    ZFYVE27 (Zinc Finger, FYVE Domain Containing 27 (ZFYVE27))
    Binding Specificity
    • 14
    • 8
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 341-411
    Reactivity
    • 45
    • 28
    • 28
    • 8
    • 6
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Rat, Mouse
    Host
    • 45
    Rabbit
    Clonality
    • 45
    Polyclonal
    Conjugate
    • 16
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ZFYVE27 antibody is conjugated to Biotin
    Application
    • 39
    • 17
    • 13
    • 13
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Predicted Reactivity
    Dog,Cow,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human ZFYVE27
    Isotype
    IgG
    Top Product
    Discover our top product ZFYVE27 Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    ZFYVE27 (Zinc Finger, FYVE Domain Containing 27 (ZFYVE27))
    Alternative Name
    ZFYVE27 (ZFYVE27 Products)
    Synonyms
    ZFYVE27 antibody, MGC130947 antibody, spg33 antibody, im:7137347 antibody, zgc:153156 antibody, PROTRUDIN antibody, RP11-459F3.2 antibody, SPG33 antibody, 2210011N02Rik antibody, 9530077C24Rik antibody, AI426636 antibody, AI593546 antibody, AI835681 antibody, zinc finger FYVE-type containing 27 antibody, zinc finger FYVE domain containing 27 L homeolog antibody, zinc finger FYVE domain containing 27 antibody, zinc finger, FYVE domain containing 27 antibody, ZFYVE27 antibody, zfyve27.L antibody, zfyve27 antibody, Zfyve27 antibody
    Background

    Synonyms: Protrudin, RP11 459F3.2, SPG33, ZFY27_HUMAN, ZFYVE27, zinc finger FYVE domain containing 27, Zinc finger FYVE domain containing protein 27, Zinc finger FYVE domain-containing protein 27.

    Background: Zinc finger FYVE domain-containing protein 27 (ZFYVE27), also known as SPG33, is a 411 amino acid member of the FYVE-finger family of proteins. The FYVE domain is a cysteine-rich domain of about 70 amino acids that plays a role in the endosomal localization of the FYVE-finger proteins, and a majority of these proteins serve as regulators of endocytic membrane trafficking. ZFYVE27, a multi-pass membrane protein, is an endosomal protein that binds to Spastin, a protein that is primarily involved in microtubule dynamics and severing, vesicular trafficking and endosomal trafficking. Mutations in the gene encoding ZFTVE27 affect neuronal intracellular trafficking in the corticospinal tract and are thought to lead to hereditary spastic paraplegia (HSP), a neurodegenerative disorder, characterized by progressive paralysis of the legs, which is caused by impaired axonal transport. Five isoforms of ZFYVE27 exist as a result of alternative splicing events.

    Gene ID
    118813
    UniProt
    Q5T4F4
    Pathways
    Neurotrophin Signaling Pathway
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