RNF146 antibody (AA 95-160) (AbBy Fluor® 488)

Catalog No. ABIN1392634

Product Details anti-RNF146 Antibody (AbBy Fluor® 488)

Target: RNF146 (Ring Finger Protein 146 (RNF146))

Binding Specificity: AA 95-160

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF146 antibody is conjugated to AbBy Fluor® 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RNF146

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for RNF146

Target: RNF146 (Ring Finger Protein 146 (RNF146))

Alternative Name: RNF146 (RNF146 Products)

Synonyms: RP3-351K20.1 antibody, dJ351K20.1 antibody, 2610509H23Rik antibody, Iduna antibody, RNF146 antibody, rnf146 antibody, dactylidin antibody, wu:fi29e08 antibody, zgc:55909 antibody, ring finger protein 146 antibody, RING finger protein 146 antibody, ring finger protein 146 S homeolog antibody, RNF146 antibody, Rnf146 antibody, rn146 antibody, rnf146.S antibody, rnf146 antibody

Background:

Synonyms: Dactylidin, dJ351K20.1, DKFZP434O1427, E3 ubiquitin-protein ligase rnf146, RING finger protein 146, RN146_HUMAN, RNF 146, Rnf146, RP3 351K20.1.

Background: The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF146 (RING finger protein 146), also known as Dactylidin, is a 359 amino acid protein that contains one RING-type zinc finger and one WWE domain. Via its RING-type zinc finger, RNF146 may play a role in transcriptional regulation and protein degradation events. Defects in the gene encoding RNF146 are associated with Alzheimer's disease (AD) and may lead to a higher risk of breast cancer. Two isoforms of RNF146 exist due to alternative splicing events.