CALHM1 antibody (AA 161-260) (AbBy Fluor® 647)
-
- Target See all CALHM1 Antibodies
- CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))
-
Binding Specificity
- AA 161-260
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This CALHM1 antibody is conjugated to AbBy Fluor® 647
-
Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Predicted Reactivity
- Human,Mouse,Rat,Dog,Cow,Horse,Chicken,Rabbit
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human CALHM1/FAM26C
- Isotype
- IgG
- Top Product
- Discover our top product CALHM1 Primary Antibody
-
-
- Application Notes
-
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
-
- Target
- CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))
- Alternative Name
- CALHM1/FAM26C (CALHM1 Products)
- Synonyms
- FAM26C antibody, Fam26c antibody, RGD1564891 antibody, EG546729 antibody, calcium homeostasis modulator 1 antibody, novel protein similar to vertebrate calcium homeostasis modulator protein family antibody, CALHM1 antibody, LOC557535 antibody, Calhm1 antibody
- Background
-
Synonyms: CAHM1_HUMAN, Calcium homeostasis modulator 1, Calcium homeostasis modulator protein 1, CALHM1, FAM26C, Family with sequence similarity 26, member C, MGC39514, MGC39617, Protein FAM26C.
Background: CALHM1 is a 346 amino acid multi-pass endoplasmic reticulum membrane protein that belongs to the FAM26 family. CALHM1 co-localizes with GRP 78 to the endoplasmic reticulum. Predominantly expressed in adult brain, CALHM1 may be a pore-forming ion channel that controls cytosolic Ca2+ permeability and cytosolic Ca2+ concentration in the cell. It is suggested that CALHM1 regulates amyloid precursor protein proteolysis and aggregated amyloid-beta peptides levels in a Ca2+ dependent manner. CALHM1 homomultimerizes and shares strong sequence similarities with the selectivity filter of the NMDA receptor, which generates a large Ca2+ conductance across the plasma membrane. CALHM1 may be a potential factor involved in the pathogenesis of Alzheimer's disease.
-