APBB3 antibody (AA 401-486) (AbBy Fluor® 555)
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- Target See all APBB3 Antibodies
- APBB3 (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 3 (APBB3))
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Binding Specificity
- AA 401-486
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Reactivity
- Rat, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This APBB3 antibody is conjugated to AbBy Fluor® 555
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Cross-Reactivity
- Mouse, Rat
- Predicted Reactivity
- Human,Dog,Cow,Sheep
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human APBB3/FE65L2
- Isotype
- IgG
- Top Product
- Discover our top product APBB3 Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- APBB3 (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 3 (APBB3))
- Alternative Name
- APBB3/FE65L2 (APBB3 Products)
- Synonyms
- Fe65l2 antibody, Rirl2 antibody, TR2S antibody, MGC142933 antibody, FE65L2 antibody, SRA antibody, amyloid beta (A4) precursor protein-binding, family B, member 3 antibody, steroid receptor RNA activator 1 antibody, amyloid beta precursor protein binding family B member 3 antibody, Apbb3 antibody, SRA1 antibody, APBB3 antibody, apbb3 antibody
- Background
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Synonyms: Amyloid beta A4 precursor protein binding family B member 3, Amyloid beta A4 precursor protein-binding family B member 3, amyloid beta precursor protein binding family B member 3, amyloid precursor interacting protein, Apbb3, APBB3_HUMAN, Fe65 like protein 2, FE65L2, Protein Fe65-like 2, SRA.
Background: Fe65L2 is a 486 amino acid protein that contains one WW domain and two PID domains. Binding to the intracellular domain of the -Amyloid precursor protein, Fe65L2 is thought to modulate the internalization and, therefore, the accessibility and function of -Amyloid. Via its ability to control the intracellular accumulation of -Amyloid, Fe65L2 is thought to play a role in the pathogenesis of Alzheimer's disease. Fe65L2 exists as four alternatively spliced isoforms designated isoform I, isoform II, isoform III and isoform IV. Fe65L2 interacts with Amyloid-like protein and is encoded by a gene located on human chromosome 5, which contains 181 million base pairs and comprises nearly 6 % of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
- Gene ID
- 10307
- UniProt
- O95704
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