WWC1 antibody (AA 351-450) (Biotin)

Catalog No. ABIN1392055

Product Details anti-WWC1 Antibody (Biotin)

Target: WWC1 (WW and C2 Domain Containing 1 (WWC1))

Binding Specificity: AA 351-450

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WWC1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Sheep,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KIBRA

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for WWC1

Target: WWC1 (WW and C2 Domain Containing 1 (WWC1))

Alternative Name: KIBRA (WWC1 Products)

Synonyms: CG12600 antibody, CG33967 antibody, CG7552 antibody, Dmel\\CG33967 antibody, Kibra antibody, ORE-2 antibody, RE26350 antibody, kib antibody, l(3)02404 antibody, l(3)j5C3 antibody, l(3)neo42 antibody, HBEBP3 antibody, HBEBP36 antibody, KIBRA antibody, AA408228 antibody, AU017197 antibody, BC037006 antibody, mKIAA0869 antibody, CG33967 gene product from transcript CG33967-RB antibody, WW and C2 domain containing 1 antibody, WW, C2 and coiled-coil domain containing 1 antibody, kibra antibody, WWC1 antibody, Wwc1 antibody

Background:

Synonyms: KIBRA, HBEBP3, HBEBP36, MEMRYQTL, PPP1R168, Protein KIBRA, HBeAg-binding protein 3, Kidney and brain protein, WW domain-containing protein 1, WWC1, KIAA0869

Background: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance.

Gene ID: 23286

UniProt: Q8IX03