FADS2 antibody (AbBy Fluor® 647)

Catalog No. ABIN1391730

Product Details anti-FADS2 Antibody (AbBy Fluor® 647)

Target: FADS2 (Fatty Acid Desaturase 2 (FADS2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FADS2 antibody is conjugated to AbBy Fluor® 647

Application: Western Blotting (WB)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FADS2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P)(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FADS2

Target: FADS2 (Fatty Acid Desaturase 2 (FADS2))

Alternative Name: Fads2 (FADS2 Products)

Synonyms: D6D antibody, DES6 antibody, FADSD6 antibody, LLCDL2 antibody, SLL0262 antibody, TU13 antibody, FADS5 antibody, MSTP008 antibody, SCD1 antibody, SCDOS antibody, 2900042M13Rik antibody, Fadsd2 antibody, Fadsd6 antibody, DRD5/D6 antibody, wu:fb64c04 antibody, wu:fb69e08 antibody, zgc:112502 antibody, fatty acid desaturase 2 antibody, stearoyl-CoA desaturase antibody, fatty acid desaturase 2 L homeolog antibody, FADS2 antibody, SCD antibody, Fads2 antibody, fads2 antibody, fads2.L antibody

Background:

Synonyms: D6D, Delta6 desaturase, Delta6 fatty acid desaturase, DES 6, DES6, FADS 2, FADSD 6, FADSD6, Fatty acid desaturase 2, linoleoyl-CoA desaturase delta-6-desaturase like 2, LLCDL 2, LLCDL2, SLL0262, TU 13, TU13, FADS2_HUMAN.

Background: Members of the fatty acid desaturase (FADS) family, including FADS1, FADS2 and FADS3, regulate the desaturation of fatty acids by introducing double bonds between defined carbons of fatty acyl chains, thereby playing an essential role in the lipid metabolic pathway. Members of this family share N-terminal cytochrome b5-like domains, C-terminal multiple membrane-spanning desaturase regions and 3 histidine box motifs. FADS2 (fatty acid desaturase 2), also known as D6D, DES6, LLCDL2 or TU13, is a 444 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum and contains one cytochrome b5 heme-binding domain. Expressed in adult and fetal heart and in adult liver, brain, lung and retina, FADS2 functions as a component of a lipid metabolic pathway and catalyzes the first step in the pathway, namely the formation of unsaturated fatty acids from polyunsaturated fatty acids. Defects in the gene encoding FADS2 are the cause of cause of fatty acid delta-6-desaturase deficiency, an affliction that is characterized by skin abnormalities, corneal ulceration and growth failure. Multiple isoforms of FADS2 exist due to alternative splicing events.