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BBS10 antibody (AA 51-130) (AbBy Fluor® 647)

BBS10 Reactivity: Human WB, IF (cc), IF (p) Host: Rabbit Polyclonal AbBy Fluor® 647
Catalog No. ABIN1391706
  • Target See all BBS10 Antibodies
    BBS10 (Bardet-Biedl Syndrome 10 (BBS10))
    Binding Specificity
    • 14
    • 8
    • 8
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    AA 51-130
    Reactivity
    • 46
    • 2
    • 1
    • 1
    Human
    Host
    • 45
    • 1
    Rabbit
    Clonality
    • 46
    Polyclonal
    Conjugate
    • 14
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This BBS10 antibody is conjugated to AbBy Fluor® 647
    Application
    • 36
    • 20
    • 13
    • 12
    • 12
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human,Mouse,Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human BBS10
    Isotype
    IgG
    Top Product
    Discover our top product BBS10 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    BBS10 (Bardet-Biedl Syndrome 10 (BBS10))
    Alternative Name
    BBS10 (BBS10 Products)
    Synonyms
    MGC84945 antibody, si:dkey-30c15.16 antibody, C12orf58 antibody, RGD1560748 antibody, 1300007O09Rik antibody, AI452285 antibody, Bardet-Biedl syndrome 10 antibody, Bardet-Biedl syndrome 10 L homeolog antibody, Bardet-Biedl syndrome 10 (human) antibody, BBS10 antibody, bbs10.L antibody, bbs10 antibody, Bbs10 antibody
    Background

    Synonyms: Bardet Biedl syndrome 10 protein, Bardet Biedl syndrome 10 protein homolog, C12orf58, FLJ23560, RGD1560748, BBS10_HUMAN.

    Background: Bardet-Biedl syndrome (BBS) is a pleiotropic genetic disorder characterized by obesity, photoreceptor degeneration, polydactyly, hypogenitalism, renal abnormalities, and developmental delay. Other associated clinical findings in BBS patients include diabetes, hypertension, and congenital heart defects. BBS genes map to multiple loci and encode fourteen proteins, BBS1-BBS14. Many BBS genes encode basal body or cilia proteins, suggesting that BBS is a ciliary dysfunction disorder. BBS10 (Bardet-Biedl syndrome 10), also known as chromosome 12 open reading fame 58, C12orf58 or FLJ23560, is a novel 723 amino acid protein belonging to the TCP-1 chaperonin family. BBS10 localizes to the basal body of primary cilium and assists in protein folding upon ATP hydrolysis. Inhibition of BBS10 has been found to impair ciliogenesis, activate the glycogen synthase kinase 3 pathway and cause peroxisome proliferator-activated receptor nuclear accumulation. The gene encoding BBS10 contains two exons and maps to human chromosome 12q21.2.

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