FEZF1 antibody (AA 199-280) (Biotin)

Catalog No. ABIN1391623

Product Details anti-FEZF1 Antibody (Biotin)

Target: FEZF1 (FEZ Family Zinc Finger 1 (FEZF1))

Binding Specificity: AA 199-280

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FEZF1 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ZNF312B

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for FEZF1

Target: FEZF1 (FEZ Family Zinc Finger 1 (FEZF1))

Alternative Name: ZNF312B/FEZF1 (FEZF1 Products)

Synonyms: RGD1560480 antibody, fezf antibody, znf312b antibody, MGC145310 antibody, FEZ antibody, ZNF312B antibody, 3110069A13Rik antibody, Fez antibody, Zfp312-like antibody, fez-like antibody, fez antibody, fezf2 antibody, wu:fc29c05 antibody, wu:fc89h05 antibody, zgc:153730 antibody, Fez family zinc finger 1 antibody, FEZ family zinc finger 1 antibody, Fez family zinc finger protein 1 antibody, FEZ family zinc finger 1 S homeolog antibody, Fezf1 antibody, FEZF1 antibody, fezf1 antibody, Tsp_12536a antibody, Tsp_12536 antibody, fezf1.S antibody

Background:

Synonyms: FEZ, FEZ family zinc finger 1, Fez family zinc finger protein 1, fez like, fezf1, FEZF1_HUMAN, Zinc finger protein 312 like, Zinc finger protein 312B.

Background: Olfactory sensory neurons contain olfactory receptors, which are G protein-coupled receptor proteins that localize to the cilia and display affinity for and bind to a variety of odor molecules. Olfactory neurons send their axons from the olfactory epithelium to the olfactory bulb, which is covered by the CNS basal lamina. FEZF1 (Fez family zinc finger protein 1), also known as Forebrain Embryonic Zinc Finger and Zinc finger protein 312B, is a 475 amino acid nuclear protein that is expressed in the olfactory epithelium and hypothalamus of mice. In FEZF1-deficient mice, axons of olfactory neurons do not reach the olfactory bulb, suggesting that FEXF1 is required for the penetration of olfactory axons though the basal lamina before innervation of the olfactory bulb. When FEZF1 translocates to the nucleus, it induces KRAS overexpression, resulting in activation of ERK-signaling. Overexpression of FEZF1 leads to accelerated proliferation in cultured cells and increased tumor mass in mice. There are three isoforms of FEZF1 that are produced as a result of alternative splicing events.