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UNC5A antibody (AA 125-220) (Biotin)

UNC5A Reactivity: Human ELISA, IHC (p), IHC (fro) Host: Rabbit Polyclonal Biotin
Catalog No. ABIN1391605
  • Target See all UNC5A Antibodies
    UNC5A (Unc-5 Homolog A (UNC5A))
    Binding Specificity
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 125-220
    Reactivity
    • 28
    • 13
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 28
    • 1
    Rabbit
    Clonality
    • 28
    • 1
    Polyclonal
    Conjugate
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This UNC5A antibody is conjugated to Biotin
    Application
    • 13
    • 13
    • 7
    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Unc5a
    Isotype
    IgG
    Top Product
    Discover our top product UNC5A Primary Antibody
  • Application Notes
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    UNC5A (Unc-5 Homolog A (UNC5A))
    Alternative Name
    Unc5a/UNC5H1 (UNC5A Products)
    Synonyms
    zgc:175190 antibody, UNC5H1 antibody, Unc5h1 antibody, mKIAA1976 antibody, unc-5 netrin receptor A antibody, netrin receptor UNC5A antibody, UNC5A antibody, Tsp_02512 antibody, Tsp_13881 antibody, unc5a antibody, Unc5a antibody
    Background

    Synonyms: Netrin receptor UNC 5A, Netrin receptor UNC5A, Netrin receptor Unc5h1, Protein unc-5 homolog 1, Protein unc-5 homolog A, Unc 5 homolog 1, Unc 5 homolog A, Unc 5a, Unc5 a, Unc5 homolog 1, Unc5 homolog A, Unc5a, UNC5A_HUMAN, Unc5h1, FLJ16449, KIAA1976.

    Background: The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is downregulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung and kidney cancers. UNC5H1, also known as UNC5HA (unc-5 homolog A), is a member of the UNC5H family of proteins and is localized to the cell membrane. Three isoforms of UNC5H1 exist due to alternative splicing events.

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