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Nogo B Receptor antibody (AA 167-210) (AbBy Fluor® 647)

NUS1 Reactivity: Human WB, IF (cc), IF (p) Host: Rabbit Polyclonal AbBy Fluor® 647
Catalog No. ABIN1391448
  • Target See all Nogo B Receptor (NUS1) Antibodies
    Nogo B Receptor (NUS1)
    Binding Specificity
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 167-210
    Reactivity
    • 20
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 19
    • 1
    Rabbit
    Clonality
    • 19
    • 1
    Polyclonal
    Conjugate
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Nogo B Receptor antibody is conjugated to AbBy Fluor® 647
    Application
    • 20
    • 12
    • 12
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human NGBR/Nogo B receptor
    Isotype
    IgG
    Top Product
    Discover our top product NUS1 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    Nogo B Receptor (NUS1)
    Alternative Name
    NGBR/Nogo B receptor (NUS1 Products)
    Synonyms
    C6orf68 antibody, MGC:7199 antibody, NgBR antibody, TANGO14 antibody, 1600027K07Rik antibody, AU019165 antibody, AW538011 antibody, BC003223 antibody, D10Ertd438e antibody, NUS1 dehydrodolichyl diphosphate synthase subunit antibody, NUS1 antibody, Nus1 antibody
    Background

    Synonyms: C6orf68, NGBR, nuclear undecaprenyl pyrophosphate synthase 1 homolog, NUS1, NGBR_HUMAN, Dehydrodolichyl diphosphate synthase complex subunit NUS1, Cis-prenyltransferase subunit NgBR, Nogo-B receptor.

    Background: Nogo is an oligodendrocyte-specific member of the Reticulon family and is a component of CNS white matter that inhibits axon outgrowth, induces collapse of growth cones of chick dorsal root ganglion cells, and inhibits the spreading of 3T3 fibroblasts. Nogo is expressed by oligodendrocytes but not by Schwann cells and associates primarily with the endoplasmic reticulum. Nogo exists in three different splice forms, Nogo-A, -B and -C. NgBR (Nogo-B receptor), also known as nuclear undecaprenyl pyrophosphate synthase 1 homolog, is a 293 amino acid single-pass type I membrane protein that acts as a specific receptor for the amino-terminus of Nogo-B. Through this interaction, NgBR is involved in the regulation of vascular remodeling and angiogenesis. NgBR also enhances Niemann-Pick type C2 protein (NPC2) stabilization. Knockdown of NgBR mRNA leads to decreased NPC2 levels, which results in the hallmarks of NPC2 mutation: increased intracellular cholesterol accumulation and a loss of sterol sensing.

    Gene ID
    116150
    UniProt
    Q96E22
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