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NGEF antibody (AA 451-550) (Biotin)

NGEF Reactivity: Mouse, Rat WB, ELISA, IHC (fro), IHC (p) Host: Rabbit Polyclonal Biotin
Catalog No. ABIN1391395
  • Target See all NGEF Antibodies
    NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))
    Binding Specificity
    • 15
    • 14
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 451-550
    Reactivity
    • 40
    • 40
    • 34
    • 3
    • 3
    • 3
    • 3
    Mouse, Rat
    Host
    • 47
    • 1
    Rabbit
    Clonality
    • 47
    • 1
    Polyclonal
    Conjugate
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NGEF antibody is conjugated to Biotin
    Application
    • 38
    • 26
    • 26
    • 10
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Mouse, Rat
    Predicted Reactivity
    Human,Dog,Cow,Pig,Horse,Chicken
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human EPHEXIN
    Isotype
    IgG
    Top Product
    Discover our top product NGEF Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))
    Alternative Name
    Ephexin-1/EPHEXIN (NGEF Products)
    Synonyms
    Ephexin-1 antibody, ARHGEF27 antibody, EPHEXIN antibody, Tims2 antibody, ephexin antibody, Besh3 antibody, ephexin-1 antibody, neuronal guanine nucleotide exchange factor antibody, NGEF antibody, Ngef antibody
    Background

    Synonyms: EPHEXIN, ARHGEF27, Ephexin-1, Eph-interacting exchange protein, Neuronal guanine nucleotide exchange factor, NGEF

    Background: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).

    Gene ID
    25791
    UniProt
    Q8N5V2
    Pathways
    Neurotrophin Signaling Pathway
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