GNRHR2 antibody (AA 81-180) (AbBy Fluor® 350)
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- Target See all GNRHR2 products
- GNRHR2 (Gonadotropin-Releasing Hormone (Type 2) Receptor 2 (GNRHR2))
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Binding Specificity
- AA 81-180
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Reactivity
- Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This GNRHR2 antibody is conjugated to AbBy Fluor® 350
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Cross-Reactivity
- Pig
- Predicted Reactivity
- Human
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human GNRHR2
- Isotype
- IgG
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- GNRHR2 (Gonadotropin-Releasing Hormone (Type 2) Receptor 2 (GNRHR2))
- Alternative Name
- GNRHR2 (GNRHR2 Products)
- Synonyms
- gnrhr1/iii antibody, GnRH-II-R antibody, gonadotropin releasing hormone receptor 2 (pseudogene) antibody, gonadotropin-releasing hormone (type 2) receptor 2 antibody, gnrhr2 antibody, GNRHR2 antibody
- Background
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Synonyms: GnRH IIR, Putative gonadotropin-releasing hormone II receptor, gonadotropin-releasing hormone type 2 receptor 2, GnRH-II-R, Type II GnRH receptor, GNRR2_HUMAN.
Background: Gonadotropin-releasing hormone (GnRH) is released in a pulsatile manner that varies with the reproductive cycle. This hypothalamic hormone is transported to the pituitary, where it binds to specific receptors and regulates the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Localized to the cell membrane, GnRHR2 mediates its own receptor activity via association with G proteins, thereby activating a phosphatidylinositol-calcium second messenger system that regulates GnRHR2 function. GnRHR2 is thought to have potent antiproliferative effects on ovarian and endometrial cancer cells, suggesting a possible role in tumor suppression. Due to alternative splicing events, GnRHR2 is expressed as two isoforms.
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