Utrophin antibody (AbBy Fluor® 555)

Catalog No. ABIN1391015

Product Details anti-Utrophin Antibody (AbBy Fluor® 555)

Target: Utrophin (UTRN)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Utrophin antibody is conjugated to AbBy Fluor® 555

Application: Flow Cytometry (FACS)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Utrophin

Isotype: IgG

Application Details

Application Notes: IF(IHC-P): 1:50-200
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Utrophin

Target: Utrophin (UTRN)

Alternative Name: Utrophin (UTRN Products)

Synonyms: drp antibody, dmdl antibody, drp1 antibody, DKFZp469A0710 antibody, DMDL antibody, DRP antibody, DRP1 antibody, AA589569 antibody, Dmdl antibody, utrophin L homeolog antibody, utrophin antibody, utrn.L antibody, UTRN antibody, LOAG_03796 antibody, utrn antibody, LOC100551145 antibody, Utrn antibody

Background:

Synonyms: DMDL, DRP 1, DRP, DRP-1, DRP1, Dystrophin like protein, Dystrophin related protein 1, Dystrophin related protein, Dystrophin-related protein 1, FLJ23678, UTRN, UTRO_HUMAN, Utrophin homologous to dystrophin, Utrophin

Background: Dystrophin and utrophin are related structural, Actin-binding proteins that are involved in anchoring the cytoskeleton to the plasma membrane. Dystrophin is the protein product of the Duchenne/Becker muscular dystrophy gene. Dystrophin expression is found in muscle and brain tissues, where it is localized to the inner surface of the plasma membrane. It has been speculated that alternative splicing of the carboxy terminus allows dystrophin to interact with a variety of proteins. Research has shown that the loss of dystrophin-associated proteins in Duchenne afflicted muscle is due to the absence of dystrophin rather than to muscle degradation and that the lack of dystrophin results in the loss of linkage between the cytoskeleton and the extracellular matrix. Evidence suggests that the upregulation of utrophin can reduce the dystrophic pathology.

Gene ID: 7402

Pathways: Skeletal Muscle Fiber Development