AACS antibody (AA 182-228) (Biotin)

Catalog No. ABIN1390951

Product Details anti-AACS Antibody (Biotin)

Target: AACS (Acetoacetyl-CoA Synthetase (AACS))

Binding Specificity: AA 182-228

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AACS antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human AACS

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for AACS

Target: AACS (Acetoacetyl-CoA Synthetase (AACS))

Alternative Name: AACS/ACSF1 (AACS Products)

Synonyms: sur-5 antibody, An08g04090 antibody, AO090001000376 antibody, ACSF1 antibody, SUR-5 antibody, 2210408B16Rik antibody, SUR5 antibody, zgc:56105 antibody, acetoacetyl-CoA synthetase antibody, bll4282 antibody, acetoacetyl-coa synthetase antibody, acetoacetate--CoA ligase antibody, acetoacetate-CoA ligase antibody, Acetoacetyl-CoA synthetase antibody, AACS antibody, LOC590598 antibody, aacs antibody, bll4282 antibody, Pfl01_3080 antibody, h16_A2860 antibody, Mflv_1473 antibody, ANI_1_594074 antibody, Pput_2653 antibody, VIBHAR_RS20435 antibody, AOR_1_648164 antibody, CC1G_04522 antibody, LACBIDRAFT_230952 antibody, PLES_33261 antibody, PA1997 antibody, OB0504 antibody, CBU_0766 antibody, acsA2 antibody, Sde_0006 antibody, Plav_1154 antibody, AZC_2243 antibody, SGR_RS30655 antibody, Aacs antibody, sur-5 antibody

Background:

Synonyms: Acetoacetyl-CoA synthetase, ACSF1, Acyl-CoA synthetase family member 1, Protein sur-5 homolog, AACS_HUMAN.

Background: ACSF1 is a 672 amino acid protein belonging to the ATP-dependent AMP-binding enzyme family. Encoded by a gene that maps to human chromosome 12q24.31, ACSF1 is highly expressed in kidney, heart and brain, and shows similar neural expression as HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). Existing as three alternatively spliced isoforms, ACSF1 participates in ATP binding, ligase activity, acetoacetate-CoA ligase activity and nucleotide binding. The ACSF1 promoter is a known PPAR?target gene, with the nuclear receptor recruited to the ACSF1 promoter by direct interaction with stimulating protein-1 (Sp1). ACSF1 activates acetoacetate and is highly regulated by modulators that affect HMGCR and cholesterol biosynthesis.

Gene ID: 65985

Pathways: Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis