RIMS3 antibody (AA 21-120) (FITC)

Catalog No. ABIN1390808

Product Details anti-RIMS3 Antibody (FITC)

Target: RIMS3 (Regulating Synaptic Membrane Exocytosis 3 (RIMS3))

Binding Specificity: AA 21-120

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RIMS3 antibody is conjugated to FITC

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Horse,Chicken,Rabbit,Zebrafish

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RIMS3

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for RIMS3

Target: RIMS3 (Regulating Synaptic Membrane Exocytosis 3 (RIMS3))

Alternative Name: RIMS3 (RIMS3 Products)

Synonyms: NIM3 antibody, RIM3 antibody, Nim2 antibody, Nim3 antibody, A730060M23Rik antibody, Rim3 antibody, mKIAA0237 antibody, RIMS3 antibody, MGC145981 antibody, si:ch211-239d6.1 antibody, regulating synaptic membrane exocytosis 3 antibody, RIMS3 antibody, Rims3 antibody, rims3 antibody

Background:

Synonyms: NIM 3, NIM3, Rab 3 interacting molecule 3, Regulating synaptic membrane exocytosis 3, Regulating synaptic membrane exocytosis protein 3, RIMS 3, RIMS-3, RIM 3, RIM3, RIM3 gamma, RIMS3, RIMS3_HUMAN.

Background: Rab 3, a neural/neuroendocrine-specific member of the Rab family, is involved in Ca2+-regulated exocytosis and functions in an inhibitory capacity, controlling the recruitment and pooling of secretory vesicles at the plasma membrane. The Rim (Rab 3 interacting molecule) family of proteins (Rim1, Rim2, Rim3 and Rim4) are multidomain adaptors that regulate Rab 3 activity and sub-sequent neurotransmitter release. Rim3, also known as RIMS3 (regulating synaptic membrane exocytosis 3) or NIM3, is a 308 amino acid member of the Rim family. Localized to the synapse and to cell junctions, Rim3 contains one C2 domain and is thought to play an important role in the regulation of synaptic membrane exocytosis. Rim3, a protein that may be phosphorylated upon DNA damage, is expressed throughout the body with highest levels present in brain tissue.

Gene ID: 9783

Pathways: Stem Cell Maintenance, Synaptic Vesicle Exocytosis