Hippocalcin antibody (AA 101-193) (Biotin)

Catalog No. ABIN1390741

Product Details anti-Hippocalcin Antibody (Biotin)

Target: Hippocalcin (HPCA)

Binding Specificity: AA 101-193

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Hippocalcin antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Cow,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Hippocalcin

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for Hippocalcin

Target: Hippocalcin (HPCA)

Alternative Name: Hippocalcin (HPCA Products)

Synonyms: zgc:73126 antibody, MGC80408 antibody, MGC84992 antibody, bdr2 antibody, BDR2 antibody, hippocalcin antibody, hippocalcin S homeolog antibody, hpca antibody, hpca.S antibody, HPCA antibody, Hpca antibody

Background:

Synonyms: BDR 2, BDR2, Calcium binding protein BDR 2, Calcium binding protein BDR2, Calcium-binding protein BDR-2, Hpca, HPCA_HUMAN, Neuron specic calcium binding protein hippocalcin, Neuron specic calcium-binding protein hippocalcin, Neuron-specic calcium-binding protein hippocalcin,P23K.

Background: Hippocalcin is a neuron-specific calcium-binding protein found primarily in the plasma membrane of brain and retinal tissue, with increased expression observed in hippocampal pyramidal cells. Through its calcium-dependent signal regulation, hippocalcin can both inhibit rhodopsin kinase and increase phospholipase D2 expression. In order to regulate kinase and phospholipase activity, hippocalcin must bind to the plasma membrane where it can then bind two calcium ions for use in signal regulation. The hippocalcin protein is highly conserved in mouse, rat and human tissue and has a suggested role in neural plasticity and associative memory by contributing to the survival of neurons during aging. The loss of hippocalcin expression is thought to contribute to age-related impairment of post-synaptic functions related to neuronal degradation.